NOXO1

Description		NADPH oxidase organizer 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane NADPH Oxidase Complex
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Enzyme Binding Phosphatidylinositol Binding
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Superoxide Anion Generation Regulation Of Respiratory Burst
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Ecabet
Diseases
GWAS		Red cell distribution width ( 32888494)
Novel Interacting Genes		2 novel interacting genes: NOX1 NOXA1
Interacting Genes		2 interacting genes: NOX1 NOXA1
Entrez ID		124056
HPRD ID		14834
Ensembl ID		ENSG00000196408
Uniprot IDs		A8K832 Q8NFA2
PDB IDs		2L73
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Small GTPase Binding Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity Cellular Response To Hyperoxia Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity NAD(P)H Oxidase H2O2-forming Activity Cellular Response To Increased Oxygen Levels Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Response To Hyperoxia Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Respiratory Burst Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vascular Endothelial Growth Factor Production Hydrogen Peroxide Metabolic Process NADP+ Metabolic Process NADP Binding Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of JNK Cascade SH3 Domain Binding Nicotinamide Nucleotide Metabolic Process
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