CMA1

Description		chymase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Extracellular Matrix Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process	Angiotensin Maturation Proteolysis Peptide Metabolic Process Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Protein Maturation Cellular Response To Glucose Stimulus Cytokine Precursor Processing
Pathways		Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs		Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS
Novel Interacting Genes		10 novel interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Interacting Genes		10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		1215
HPRD ID		00346
Ensembl ID		ENSG00000092009
Uniprot IDs		P23946 Q4FEB3
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP 7H60 7H61 7H62 7H63 7H64 7H65 7H66 7H67 7H68 7H69 7H6A 7H6B 7H6C 7H6D 7H6E 7H6F 7H6I 9GBH 9GC1 9GC9 9GCC 9GCD
Enriched GO Terms of Interacting Partners?		Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vein Smooth Muscle Contraction Leukocyte Migration Vasoconstriction Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Systemic Arterial Blood Pressure Regulation Of Locomotion Positive Regulation Of Prostaglandin Biosynthetic Process Artery Smooth Muscle Contraction Neutrophil Chemotaxis Tonic Smooth Muscle Contraction Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Regulation Of Vasoconstriction Neutrophil Migration Granulocyte Chemotaxis Vascular Associated Smooth Muscle Contraction Granulocyte Migration Positive Regulation Of Fatty Acid Biosynthetic Process Hormone Activity Positive Regulation Of Heart Rate Positive Regulation Of Cellular Component Organization Circulatory System Process Regulation Of Lipid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Lipid Metabolic Process Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Heart Contraction Positive Regulation Of Fatty Acid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Small Molecule Metabolic Process Extracellular Region Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Muscle Contraction System Process Extracellular Space Cell Migration
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