CLN3

Description		CLN3 lysosomal/endosomal transmembrane protein, battenin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Caveola Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuron Projection Autolysosome Membrane Raft Synapse Recycling Endosome
	Molecular Function	Protein Binding Glycolipid Transfer Activity Calcium-dependent Protein Binding Glycolipid Binding Sulfatide Binding
	Biological Process	Action Potential Amino Acid Transport Endocytosis Receptor-mediated Endocytosis Lysosome Organization Lysosomal Lumen Acidification Learning Or Memory Associative Learning Intracellular Water Homeostasis Regulation Of Autophagy Regulation Of Fibroblast Migration Macroautophagy Regulation Of Autophagosome Size Protein Processing Intracellular Monoatomic Cation Homeostasis Actin Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Synaptic Transmission, GABAergic Ionotropic Glutamate Receptor Signaling Pathway Ceramide Transport Lysosomal Lumen PH Elevation Renal Potassium Excretion Amyloid Precursor Protein Catabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Plasma Membrane Raft Organization Negative Regulation Of Proteolysis Glycerophospholipid Biosynthetic Process Glycolipid Transport Vesicle Transport Along Microtubule Regulation Of Short-term Neuronal Synaptic Plasticity Positive Regulation Of Pinocytosis Neuromuscular Process Controlling Balance Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Filopodium Assembly Regulation Of Cytoskeleton Organization Establishment Of Localization In Cell Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Autophagosome-lysosome Fusion Regulation Of Biological Quality Regulation Of Protein Processing Protein Localization To Membrane Protein Localization To Plasma Membrane Golgi To Lysosome Transport Phagosome-lysosome Docking Phagosome-lysosome Fusion Autophagosome Maturation Regulation Of Cellular Response To Osmotic Stress Regulation Of Arginine Biosynthetic Process Regulation Of Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane L-arginine Transmembrane Transport Lysosomal Protein Catabolic Process Regulation Of Phagosome Maturation Regulation Of Modification Of Synaptic Structure Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Glycosphingolipid transport
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Bullous pemphigoid ( 34011352) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252) Type 1 diabetes ( 30572963)
Novel Interacting Genes		2 novel interacting genes: KCNIP3 SBDS
Interacting Genes		2 interacting genes: KCNIP3 SBDS
Entrez ID		1201
HPRD ID		08450
Ensembl ID		ENSG00000188603
Uniprot IDs		B4DFF3 B4DMY6 Q13286 Q2TA70
PDB IDs
Enriched GO Terms of Interacting Partners?
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