TPP1

Description		tripeptidyl peptidase 1
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GO Annotations	Cellular Component	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Hydrolase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process
Pathways		XBP1(S) activates chaperone genes
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Malaria ( 31844061)
Novel Interacting Genes		9 novel interacting genes: CTC1 DSCR9 LCOR NMB OGT POT1 STN1 TERT TINF2
Interacting Genes		9 interacting genes: CTC1 DSCR9 LCOR NMB OGT POT1 STN1 TERT TINF2
Entrez ID		1200
HPRD ID		06415
Ensembl ID		ENSG00000166340
Uniprot IDs		O14773
PDB IDs		3EDY 3EE6
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process CST Complex Telomere Assembly Single-stranded Telomeric DNA Binding Shelterin Complex Regulation Of Chromosome Organization Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process DNA Metabolic Process Negative Regulation Of Biosynthetic Process Replicative Senescence Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of DNA Replication Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Neuromedin B Receptor Binding TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription
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