CLCN6

Description		chloride voltage-gated channel 6
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Endosome Membrane Membrane Late Endosome Membrane
	Molecular Function	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Cell Volume Homeostasis Signal Transduction Response To Mechanical Stimulus Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Natriuretic peptide levels ( 21273288) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red cell distribution width ( 32888494) Systolic blood pressure ( 19430483 29615537 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 28604728) Tuberculosis ( 29036319)
Novel Interacting Genes		2 novel interacting genes: ERBB2 TNFRSF8
Interacting Genes		2 interacting genes: ERBB2 TNFRSF8
Entrez ID		1185
HPRD ID		04102
Ensembl ID		ENSG00000011021
Uniprot IDs		P51797
PDB IDs		8JPJ 8JPO 8JPR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TRAIL Production Regulation Of TRAIL Production Transmembrane Signaling Receptor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Immature T Cell Proliferation In Thymus Semaphorin Receptor Complex Negative Regulation Of Cell Population Proliferation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Motor Neuron Axon Guidance Peripheral Nervous System Development Regulation Of T Cell Differentiation In Thymus ERBB2 Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Rho Protein Signal Transduction Regulation Of Protein Targeting To Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of Transcription By RNA Polymerase I Myelin Sheath Protein Localization To Postsynapse Positive Regulation Of MAP Kinase Activity Neuromuscular Junction Development Positive Regulation Of Gene Expression Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Oligodendrocyte Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Transcription By RNA Polymerase I Response To Epidermal Growth Factor Semaphorin-plexin Signaling Pathway Receptor Localization To Synapse Negative Regulation Of T Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Negative Regulation Of T Cell Proliferation Protein Localization To Synapse
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