CLCN2

Description		chloride voltage-gated channel 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Axon Dendrite Dendritic Spine Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Axon Initial Segment Perikaryon Myelin Sheath Synapse Postsynaptic Membrane Astrocyte End-foot
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Voltage-gated Monoatomic Anion Channel Activity Chloride Transmembrane Transporter Activity Chloride Channel Regulator Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Phagocytosis, Engulfment Stabilization Of Membrane Potential Lung Development Regulation Of Aldosterone Biosynthetic Process Monoatomic Ion Transmembrane Transport Positive Regulation Of Oligodendrocyte Differentiation Transmembrane Transport Retina Development In Camera-type Eye Regulation Of Resting Membrane Potential Cell Differentiation Involved In Salivary Gland Development Regulation Of Biological Quality Cellular Hypotonic Response Acinar Cell Differentiation Monoatomic Anion Transmembrane Transport Regulation Of Membrane Depolarization During Action Potential Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels
Drugs		Lubiprostone Cobiprostone
Diseases		Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		General cognitive ability ( 29844566)
Novel Interacting Genes		5 novel interacting genes: ATXN1 BRD2 FHL3 PPP1CA UBQLN1
Interacting Genes		5 interacting genes: ATXN1 BRD2 FHL3 PPP1CA UBQLN1
Entrez ID		1181
HPRD ID		02782
Ensembl ID		ENSG00000114859
Uniprot IDs		P51788
PDB IDs		7XF5 7XJA 8GQU 8TA2 8TA3 8TA4 8TA5 8TA6
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Postsynapse Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Positive Regulation Of T-helper 17 Cell Lineage Commitment Poly(G) Binding POZ Domain Binding Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Tagcloud ?