TOP1MT

Description		DNA topoisomerase I mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrion Mitochondrial Nucleoid
	Molecular Function	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Isomerase Activity
	Biological Process	DNA Replication DNA Topological Change
Pathways
Drugs		Irinotecan Topotecan
Diseases
GWAS		Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Novel Interacting Genes		3 novel interacting genes: TP53 TSNARE1 UBC
Interacting Genes		3 interacting genes: TP53 TSNARE1 UBC
Entrez ID		116447
HPRD ID		16214
Ensembl ID		ENSG00000184428
Uniprot IDs		B4DYD2 E5KMK7 Q969P6
PDB IDs
Enriched GO Terms of Interacting Partners?		Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity Ubiquitin Protein Ligase Binding B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Regulation Of Thymocyte Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of ATP-dependent Activity ER Overload Response Mitotic G1 DNA Damage Checkpoint Signaling MDM2/MDM4 Family Protein Binding TFIID-class Transcription Factor Complex Binding Lactate Metabolic Process Replicative Senescence Positive Regulation Of Programmed Necrotic Cell Death Type II Interferon-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Cellular Response To Antibiotic Negative Regulation Of Mitophagy Necroptotic Process Intracellular Protein Transport
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