SLC22A12

Description		solute carrier family 22 member 12
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Urate Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Monoatomic Ion Transport Response To Xenobiotic Stimulus Organic Anion Transport Urate Transport Cellular Homeostasis Cellular Response To Insulin Stimulus Urate Metabolic Process Transmembrane Transport Renal Urate Salt Excretion
Pathways		Organic anion transport by SLC22 transporters Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Drugs		Sulfinpyrazone Lesinurad
Diseases		Renal hypouricemia (RHUC)
GWAS		Gout ( 27899376) Gout (combined type) ( 32238385) Hyperuricemia ( 29124443) Renal function-related traits (urate) ( 22797727) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376) Serum uric acid levels ( 32514006 30993211 29124443 26902266) Systemic lupus erythematosus ( 26606652) Urate levels ( 23263486 21768215 31578528 31985003 20139978) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Novel Interacting Genes		1 novel interacting genes: PDZK1
Interacting Genes		1 interacting genes: PDZK1
Entrez ID		116085
HPRD ID		06160
Ensembl ID		ENSG00000197891
Uniprot IDs		B3KP53 Q96S37
PDB IDs		8WJG 8WJQ 9B1F 9B1G 9B1H 9B1I 9B1J 9B1K 9B1L 9B1M 9B1N 9B1O 9IRW 9IRX 9IRY 9JDV 9JDY 9JDZ 9JE0 9JE1
Enriched GO Terms of Interacting Partners?		Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Scavenger Receptor Binding Carnitine Transmembrane Transport Amino-acid Betaine Transport Carnitine Transport Quaternary Ammonium Group Transport Transporter Activator Activity Microvillus Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Protein Targeting To Membrane Protein-membrane Adaptor Activity Xenobiotic Transport Brush Border Membrane Export Across Plasma Membrane Brush Border Organic Cation Transport Positive Regulation Of Protein Localization To Membrane PDZ Domain Binding Regulation Of Protein Localization To Membrane Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Protein-containing Complex Binding Apical Plasma Membrane Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization
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