ARHGEF25

Description		Rho guanine nucleotide exchange factor 25
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Myofibril Sarcomere
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (q) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653 30578418)
Novel Interacting Genes		5 novel interacting genes: CDC42 PRKCG RAC1 RHOA RHOU
Interacting Genes		5 interacting genes: CDC42 PRKCG RAC1 RHOA RHOU
Entrez ID		115557
HPRD ID		13573
Ensembl ID		ENSG00000240771
Uniprot IDs		Q86VW2
PDB IDs		2RGN
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly GTPase Activity G Protein Activity Regulation Of Cell-substrate Junction Organization GTP Binding Actin Cytoskeleton Organization Establishment Of Cell Polarity Actin Filament-based Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Focal Adhesion Cell Projection Protein Kinase Binding Dendrite Thioesterase Binding Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Nucleotide Binding Cell-cell Junction Organization Intracellular Signal Transduction Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Postsynapse Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Intracellular Signaling Cassette Establishment Of Epithelial Cell Polarity Phagocytosis, Engulfment Regulation Of Actin Filament Organization Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Cytoskeleton Organization Regulation Of Synapse Organization Regulation Of Cellular Component Organization Telencephalon Cell Migration
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