C1QTNF4

Description		C1q and TNF related 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Gene Expression Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Neuroticism ( 29255261) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Sleep duration (short sleep) ( 30846698)
Novel Interacting Genes		4 novel interacting genes: L3MBTL3 TEPSIN UBQLN1 UBQLN2
Interacting Genes		4 interacting genes: L3MBTL3 TEPSIN UBQLN1 UBQLN2
Entrez ID		114900
HPRD ID		12717
Ensembl ID		ENSG00000172247
Uniprot IDs		Q9BXJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Autophagosome Positive Regulation Of Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Negative Regulation Of Store-operated Calcium Channel Activity Coated Vesicle Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Cytoplasmic Vesicle Negative Regulation Of G Protein-coupled Receptor Internalization Vacuole Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Methylation-dependent Protein Binding Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Clathrin-dependent Endocytosis Response To Endoplasmic Reticulum Stress Autophagy Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Negative Regulation Of Transport Negative Regulation Of Receptor Internalization Identical Protein Binding Regulation Of Clathrin-dependent Endocytosis Proteasomal Protein Catabolic Process Erythrocyte Maturation Regulation Of Cellular Response To Stress Regulation Of Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transporter Activity Modification-dependent Protein Catabolic Process Granulocyte Differentiation Negative Regulation Of Receptor-mediated Endocytosis Protein Catabolic Process Aggresome Proteolysis Involved In Protein Catabolic Process
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