CHRND

Description		cholinergic receptor nicotinic delta subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Brain lesion load ( 19010793) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: AGPS BMPR2 CHRNA1 GRB2 SNCA
Interacting Genes		5 interacting genes: AGPS BMPR2 CHRNA1 GRB2 SNCA
Entrez ID		1144
HPRD ID		01516
Ensembl ID		ENSG00000135902
Uniprot IDs		B4E3W4 Q07001
PDB IDs
Enriched GO Terms of Interacting Partners?		Excitatory Postsynaptic Potential Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Alkylglycerone-phosphate Synthase Activity Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Grb2-EGFR Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Semi-lunar Valve Development Skeletal Muscle Tissue Growth Cell Cortex Protein Domain Specific Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Receptor-mediated Endocytosis Neurotrophin TRKA Receptor Binding Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Presynapse Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Synapse Organization Regulation Of Chaperone-mediated Autophagy
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