CHRNB2

Description		cholinergic receptor nicotinic beta 2 subunit
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GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Cation Channel Complex Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Synaptic Membrane Neurotransmitter Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding
	Biological Process	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Methadone Dextromethorphan Cisatracurium Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Lung function (FEV1) ( 30175238) Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Novel Interacting Genes		4 novel interacting genes: CHRNA2 CHRNA4 CRELD2 SNCA
Interacting Genes		4 interacting genes: CHRNA2 CHRNA4 CRELD2 SNCA
Entrez ID		1141
HPRD ID		00335
Ensembl ID		ENSG00000160716
Uniprot IDs		P17787 Q5SXY3
PDB IDs		2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF 8SSZ 8ST0 8ST1 8ST2 8ST3 8ST4
Enriched GO Terms of Interacting Partners?		Excitatory Postsynaptic Potential Regulation Of Postsynaptic Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Cation Channel Complex Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Trans-synaptic Signaling Extracellular Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Neuromuscular Synaptic Transmission Chemical Synaptic Transmission Regulation Of Catecholamine Secretion Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Regulation Of Membrane Potential Synaptic Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Amine Transport Cell-cell Signaling Neuron Projection Cytoplasm Signaling Cell Communication Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Adult Behavior Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Monoatomic Ion Channel Activity Synapse Quaternary Ammonium Group Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Synaptic Plasticity Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Transmembrane Signaling Receptor Activity Presynapse Postsynaptic Membrane Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
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