ADCY8

Description		adenylate cyclase 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola Clathrin-coated Pit Postsynaptic Density Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Neuronal Cell Body Membrane Presynaptic Membrane Cell Projection Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Actin Binding Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Lyase Activity Phosphorus-oxygen Lyase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Protein Phosphatase 2A Binding
	Biological Process	CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Memory Long-term Memory Locomotory Behavior Cyclic Nucleotide Biosynthetic Process Glucose Mediated Signaling Pathway Positive Regulation Of Synaptic Plasticity Positive Regulation Of Insulin Secretion Positive Regulation Of CREB Transcription Factor Activity Activation Of Protein Kinase A Activity Intracellular Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus G Protein-coupled Opioid Receptor Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Protein Complex Oligomerization Protein Homooligomerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Morphine Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Regulation Of Cellular Response To Stress Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 26955885) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in ever smokers ( 28604730) Mild to moderate chronic kidney disease ( 31178898) Morning vs. evening chronotype ( 26955885) Post-traumatic stress disorder ( 24677629) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Visceral adipose tissue ( 26480920)
Novel Interacting Genes		3 novel interacting genes: CALM1 CALM2 PPP2CA
Interacting Genes		3 interacting genes: CALM1 CALM2 PPP2CA
Entrez ID		114
HPRD ID		00051
Ensembl ID		ENSG00000155897
Uniprot IDs		A0A0K0K1K3 P40145 Q4F7X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Spindle Pole Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Calcium Channel Inhibitor Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Response To Metal Ion Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Regulation Of Cell Cycle Process Vesicle-mediated Transport In Synapse
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