PLCD3

Description		phospholipase C delta 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Cleavage Furrow
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Angiogenesis Lipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Regulation Of Cell Population Proliferation Labyrinthine Layer Blood Vessel Development
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Asthma ( 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 27618452) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertension ( 31879980) Male-pattern baldness ( 28196072) Pulse pressure ( 27841878) Systolic blood pressure ( 19430483 27618447 27618452 27841878) Triglyceride levels ( 32203549)
Novel Interacting Genes		1 novel interacting genes: SKIL
Interacting Genes		1 interacting genes: SKIL
Entrez ID		113026
HPRD ID		07146
Ensembl ID		ENSG00000161714
Uniprot IDs		Q8N3E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Response To Antibiotic Lens Fiber Cell Differentiation Positive Regulation Of Axonogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Leukocyte Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Blastocyst Formation Positive Regulation Of Apoptotic Signaling Pathway Striated Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Muscle Structure Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axonogenesis Muscle Tissue Development Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Acrosomal Vesicle Homeostasis Of Number Of Cells PML Body
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