MAN1B1

Description		mannosidase alpha class 1B member 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Endoplasmic Reticulum Quality Control Compartment Extracellular Vesicle
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Viral Protein Processing ERAD Pathway Protein Alpha-1,2-demannosylation Endoplasmic Reticulum Mannose Trimming
Pathways		Defective MAN1B1 causes MRT15 ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs		1,4-Butanediol Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Kifunensine Duvoglustat
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 33772158) Initial alcohol sensitivity ( 30276832)
Novel Interacting Genes		4 novel interacting genes: DNM2 GOLPH3 GOLPH3L WDR5
Interacting Genes		4 interacting genes: DNM2 GOLPH3 GOLPH3L WDR5
Entrez ID		11253
HPRD ID		05068
Ensembl ID		ENSG00000177239
Uniprot IDs		H0YG20 Q9UKM7
PDB IDs		1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7
Enriched GO Terms of Interacting Partners?		Vesicle Budding From Membrane Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Post-Golgi Vesicle-mediated Transport Golgi Cisterna Golgi Vesicle Transport Phosphatidylinositol-4-phosphate Binding Vesicle Organization Golgi To Plasma Membrane Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Membrane Organization Golgi Membrane Histone H3Q5ser Reader Activity Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Membrane Tubulation Vesicle Scission Histone H3K4me1 Reader Activity Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Localization To Plasma Membrane Protein Targeting Establishment Of Protein Localization To Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Vesicle-mediated Transport Positive Regulation Of Protein Transport Membrane Tubulation Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Apparatus Positive Regulation Of Secretion By Cell Protein Localization To Membrane Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization MLL1/2 Complex Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Transferrin Transport
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