EGLN2

Description		egl-9 family hypoxia inducible factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Cellular Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Ascorbic acid Roxadustat Daprodustat Vadadustat
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838) Chronic obstructive pulmonary disease in current smokers ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (2df) ( 33106845) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Nicotine metabolite ratio in current smokers ( 28921760) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Smoking behavior ( 20418890) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Novel Interacting Genes		12 novel interacting genes: A2M CDK2 EPAS1 ETS2 HIF1A HIF3A MFHAS1 MOB4 PRKCA SPOP SRPK2 TENT5A
Interacting Genes		12 interacting genes: A2M CDK2 EPAS1 ETS2 HIF1A HIF3A MFHAS1 MOB4 PRKCA SPOP SRPK2 TENT5A
Entrez ID		112398
HPRD ID		06970
Ensembl ID		ENSG00000269858
Uniprot IDs		Q96KS0
PDB IDs		5V1B
Enriched GO Terms of Interacting Partners?		Intracellular Oxygen Homeostasis Angiogenesis Nuclear Speck Anatomical Structure Formation Involved In Morphogenesis Transcription Regulator Complex Regulation Of Protein Neddylation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Embryonic Placenta Development Epithelial Cell Maturation Cellular Response To Oxygen Levels Protein Dimerization Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-serine Phosphorylation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Domain Specific Binding Chromatin Regulation Of RNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Phosphorylation Positive Regulation Of Chromatin Organization Protein Serine Kinase Activity Nucleoplasm Regulation Of Primary Metabolic Process Protein Phosphorylation Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Tissue Remodeling Response To Hypoxia Response To Oxygen Levels Response To Oxidative Stress Response To Decreased Oxygen Levels DNA-binding Transcription Factor Activity Erythrocyte Differentiation Cis-regulatory Region Sequence-specific DNA Binding Myoblast Fate Commitment Ectodermal Cell Fate Commitment
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