POLG2

Description		DNA polymerase gamma 2, accessory subunit
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	DNA Binding Double-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding DNA Polymerase Processivity Factor Activity Identical Protein Binding DNA Polymerase Binding
	Biological Process	In Utero Embryonic Development DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication Mitochondrion Organization Mitochondrial DNA Metabolic Process DNA Biosynthetic Process Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Transcriptional activation of mitochondrial biogenesis Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: MARCHF5
Interacting Genes		1 interacting genes: MARCHF5
Entrez ID		11232
HPRD ID		09228
Ensembl ID		ENSG00000256525
Uniprot IDs		E5KS15 Q9UHN1
PDB IDs		2G4C 3IKL 3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5R
Enriched GO Terms of Interacting Partners?		CGAS/STING Signaling Pathway Regulation Of Mitochondrial Fission GTPase Binding Protein K27-linked Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Localization To Mitochondrion Canonical Inflammasome Complex Assembly Positive Regulation Of Mitochondrial Fission NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Peroxisomal Membrane Protein K63-linked Ubiquitination Protein Autoubiquitination Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Ubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Mitochondrion Organization Peroxisome Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway
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