POLR3A

Description		RNA polymerase III subunit A
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol Membrane
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Immune System Process DNA-templated Transcription Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production TRNA Transcription By RNA Polymerase III Innate Immune Response Defense Response To Virus
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Executive function (trail making test B) ( 24629169)
Novel Interacting Genes		6 novel interacting genes: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E
Interacting Genes		6 interacting genes: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E
Entrez ID		11128
HPRD ID		17879
Ensembl ID		ENSG00000148606
Uniprot IDs		O14802
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Ubiquitin Ligase Complex Channel Inhibitor Activity Regulation Of Sodium Ion Transport Formation Of Structure Involved In A Symbiotic Process 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Maintenance Of Protein Localization At Cell Tip Transmembrane Transporter Binding Innate Immune Response Phosphothreonine Residue Binding Linear Polyubiquitin Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Defense Response To Other Organism Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Macroautophagy Negative Regulation Of Potassium Ion Export Across Plasma Membrane Defense Response To Symbiont Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Nucleus Sodium Channel Inhibitor Activity Protein Domain Specific Binding Tetrahydrobiopterin Biosynthetic Process Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Desmosome Assembly IkappaB Kinase Complex Tetrahydrobiopterin Metabolic Process Potassium Channel Inhibitor Activity Alpha-catenin Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Regulation Of Ventricular Cardiac Muscle Cell Action Potential Transferrin Receptor Binding Anoikis Endocardial Cushion Development Response To Other Organism Negative Regulation Of Sodium Ion Transport Pteridine-containing Compound Biosynthetic Process Desmosome Organization
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