PTPRT

Description		protein tyrosine phosphatase receptor type T
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity Thiolester Hydrolase Activity Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Alpha-actinin Binding Delta-catenin Binding STAT Family Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Migration Neuron Projection Development Cellular Response To Interleukin-6 Negative Regulation Of Receptor Signaling Pathway Via STAT
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Anxiety and stress-related disorders ( 31116379) BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Eye morphology ( 29921221) Facial attractiveness (male raters) ( 30946739) Fractional exhaled nitric oxide (childhood) ( 24315451) Gastroesophageal reflux disease ( 34187846) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Periodontitis (Mean PAL) ( 24024966) Problematic alcohol use in trauma-exposed individuals ( 29082582) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Recurrence of mild malaria attacks ( 31667592) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878) Temporal pole volume ( 31530798) Urate levels in obese individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196)
Novel Interacting Genes		7 novel interacting genes: EGFR ERBB2 ERBB4 IL17RA PTGFR PTPRN SRC
Interacting Genes		7 interacting genes: EGFR ERBB2 ERBB4 IL17RA PTGFR PTPRN SRC
Entrez ID		11122
HPRD ID		06690
Ensembl ID		ENSG00000196090
Uniprot IDs		A0A075B6H0 O14522
PDB IDs		2OOQ
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphate Metabolic Process ERBB2-EGFR Signaling Pathway Response To Growth Factor ERBB4 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Ruffle Membrane Negative Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Protein Kinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Kinase Activity Regulation Of Protein Modification Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Apoptotic Process Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Programmed Cell Death Plasma Membrane
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