PRDM5

Description		PR/SET domain 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Chromatin Organization Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extracellular Matrix Organization Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases
GWAS		F-cell distribution in sickle cell anaemia ( 21326311) Fasting plasma glucose ( 17903298) Hemoglobin levels ( 33491795) Loneliness (multivariate analysis) ( 27629369) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Sensorimotor dexterity ( 31596458)
Novel Interacting Genes		7 novel interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1
Interacting Genes		7 interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1
Entrez ID		11107
HPRD ID		17902
Ensembl ID		ENSG00000138738
Uniprot IDs		Q9NQX1
PDB IDs		6XAZ
Enriched GO Terms of Interacting Partners?		ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Interleukin-12 Receptor Complex Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Poly(ADP-ribose) Glycohydrolase Activity Voltage-gated Chloride Channel Activity Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Receptor Complex Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Response To Superoxide Response To Oxygen Radical Protein De-ADP-ribosylation O-acetyl-ADP-ribose Deacetylase Activity Ubiquitin-modified Protein Reader Activity Action Potential Propagation Neuronal Action Potential Propagation
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