STON1

Description		stonin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Clathrin-coated Pit Synaptic Vesicle Membrane AP-2 Adaptor Complex Cell Leading Edge Cell Projection
	Molecular Function	Clathrin Adaptor Activity Cargo Adaptor Activity
	Biological Process	Endocytosis Substrate-dependent Cell Migration Regulation Of Endocytosis Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Ruffle Assembly Focal Adhesion Disassembly
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Hepcidin/ferritin ratio ( 27846281) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Macular thickness ( 30535121) Postoperative atrial fibrillation after cardiac surgery ( 30678657) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		2 novel interacting genes: RTN4 SRPK2
Interacting Genes		2 interacting genes: RTN4 SRPK2
Entrez ID		11037
HPRD ID		16100
Ensembl ID		ENSG00000243244
Uniprot IDs		B2RB25 Q9Y6Q2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Organization Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Nuclear Speck Organization Cell Migration Involved In Vasculogenesis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Intracellular Sphingolipid Homeostasis Endoplasmic Reticulum Tubular Network Formation Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Cerebral Cortex Radial Glia-guided Migration Positive Regulation Of Artery Morphogenesis R-loop Processing Regulation Of Artery Morphogenesis Positive Regulation Of Hepatocyte Proliferation Nuclear Pore Complex Assembly Regulation Of Toll-like Receptor 9 Signaling Pathway Nuclear Body Organization Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Rac Protein Signal Transduction Regulation Of Vasculogenesis Endoplasmic Reticulum Tubular Network Organization Regulation Of Hepatocyte Proliferation Cerebral Cortex Radially Oriented Cell Migration Regulation Of Mammary Gland Epithelial Cell Proliferation Axonal Fasciculation Nuclear Pore Organization Neuron Projection Fasciculation Leukocyte Migration Involved In Inflammatory Response Endoplasmic Reticulum Membrane Organization Pore Complex Assembly Endoplasmic Reticulum Tubular Network Blastocyst Formation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Migration Glial Cell Migration Cardiac Epithelial To Mesenchymal Transition 14-3-3 Protein Binding Positive Regulation Of Viral Genome Replication Cerebral Cortex Cell Migration Negative Regulation Of Axon Extension Regulation Of Rac Protein Signal Transduction
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