CHAT

Description		choline O-acetyltransferase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Neuron Projection Synapse
	Molecular Function	Choline O-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process	Phosphatidylcholine Biosynthetic Process Neurotransmitter Transport Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process
Pathways		Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs		Nicotine
Diseases		Congenital myasthenic syndrome
GWAS		Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Novel Interacting Genes		10 novel interacting genes: CAMK2A CAMK2G KCNQ3 NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Interacting Genes		10 interacting genes: CAMK2A CAMK2G KCNQ3 NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Entrez ID		1103
HPRD ID		07510
Ensembl ID		ENSG00000070748
Uniprot IDs		P28329 Q6LEN5 Q6LEN6
PDB IDs		2FY2 2FY3 2FY4 2FY5 7AMD
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Protein Phosphorylation Long-term Synaptic Potentiation Phosphorylation Regulation Of Synaptic Plasticity ATP Binding Regulation Of Protein Localization Histone H3T6 Kinase Activity Nucleotide Binding Regulation Of Biological Quality Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Positive Regulation Of Immune System Process Regulation Of Secretion By Cell Positive Regulation Of Protein Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Secretion Response To Hormone Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Neurotransmitter Secretion Positive Regulation Of Insulin Secretion Mitotic Nuclear Membrane Disassembly Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Peptide Hormone Secretion Nuclear Membrane Disassembly Positive Regulation Of Peptide Secretion Membrane Disassembly Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Response To Morphine
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