SPINK5

Description		serine peptidase inhibitor Kazal type 5
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cell Cortex Perinuclear Region Of Cytoplasm Epidermal Lamellar Body
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Antibacterial Peptide Production Epidermal Cell Differentiation Negative Regulation Of Angiogenesis Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Epithelial Cell Differentiation Hair Cell Differentiation Regulation Of T Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Timing Of Anagen
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases		Netherton syndrome
GWAS		Blood protein levels ( 30072576)
Novel Interacting Genes		1 novel interacting genes: PRSS1
Interacting Genes		1 interacting genes: PRSS1
Entrez ID		11005
HPRD ID		05423
Ensembl ID		ENSG00000133710
Uniprot IDs		Q9NQ38
PDB IDs		1H0Z 1HDL 1UUC 1UVF 1UVG 5YHN
Enriched GO Terms of Interacting Partners?		Digestion Extracellular Matrix Disassembly Serine-type Peptidase Activity Serine-type Endopeptidase Activity Blood Microparticle Extracellular Structure Organization Extracellular Matrix Organization
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