FERMT2

Description		FERM domain containing kindlin 2
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GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Cell Junction Lamellipodium Membrane I Band Cell Projection Anchoring Junction
	Molecular Function	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Actin Filament Binding Protein Serine/threonine Kinase Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Vascular Permeability Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Limb Development Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways		Cell-extracellular matrix interactions RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 30054594 31959993) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244)
Novel Interacting Genes		9 novel interacting genes: APP CMTM5 CTNNB1 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Interacting Genes		9 interacting genes: APP CMTM5 CTNNB1 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		10979
HPRD ID		06374
Ensembl ID		ENSG00000073712
Uniprot IDs		Q96AC1
PDB IDs		2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell Adhesion Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Neural Precursor Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Cell-matrix Adhesion Developmental Cell Growth Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Regulation Of Neurotransmitter Uptake Integrin Binding Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Neuroblast Proliferation Lamellipodium Cell Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Heterotypic Cell-cell Adhesion Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Canonical Wnt Signaling Pathway Intercalated Disc Regulation Of Neuroblast Proliferation Neuroblast Proliferation Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Junction Assembly Perinuclear Region Of Cytoplasm Cellular Response To Growth Factor Stimulus Positive Regulation Of Neural Precursor Cell Proliferation Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Visual Behavior Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Visual Learning
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