SPIN1

Description		spindlin 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Spindle Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Histone H3K4me3 Reader Activity Histone Reader Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Gamete Generation RRNA Transcription Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle Protein Localization To Chromatin Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways
Drugs
Diseases
GWAS		Height ( 18391951 20881960 31562340) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Novel Interacting Genes		6 novel interacting genes: GABBR2 HMGB1 HSPB1 PRMT6 PTN RPL5
Interacting Genes		6 interacting genes: GABBR2 HMGB1 HSPB1 PRMT6 PTN RPL5
Entrez ID		10927
HPRD ID		18096
Ensembl ID		ENSG00000106723
Uniprot IDs		Q9Y657
PDB IDs		2NS2 4H75 4MZF 4MZG 4MZH 5JSG 5JSJ 5Y5W 6I8B 6I8L 6I8Y 6QPL 7BQZ 7BU9 7CNA 7E9M 7EA1 7OCB 8GTX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chemotaxis Regulation Of Endothelial Cell Migration Regulation Of Chemotaxis Base-excision Repair Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Catalytic Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Hemopoiesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Protein Kinase C Signaling Dendrite Regeneration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Leukocyte Chemotaxis C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Protein Kinase C Inhibitor Activity Ossification Involved In Bone Remodeling Negative Regulation Of Proteolysis GABA Receptor Complex Histone Arginine N-methyltransferase Activity Integrin Binding Positive Regulation Of Leukocyte Migration Negative Regulation Of Catalytic Activity Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation
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