DBF4

Description		DBF4-CDC7 kinase regulatory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Novel Interacting Genes		19 novel interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK1 CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Interacting Genes		19 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK1 CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		10926
HPRD ID		10371
Ensembl ID		ENSG00000006634
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process Chromosome, Telomeric Region Nucleic Acid Metabolic Process Nuclear Origin Of Replication Recognition Complex Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Origin Recognition Complex Regulation Of DNA-templated DNA Replication Initiation DNA Repair CMG Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Replication Origin Binding Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Mitotic DNA Replication Initiation Nucleus Cellular Response To Stress Mitotic DNA Integrity Checkpoint Signaling Chromosome ATP Binding DNA Helicase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle G2/M Phase Transition Helicase Activity Nucleotide Binding DNA Strand Elongation Involved In DNA Replication Mitotic DNA Damage Checkpoint Signaling DNA Strand Elongation Negative Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Chromatin Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Response To Stress
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