PAPOLA

Description		poly(A) polymerase alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding Metal Ion Binding Poly(A) RNA Polymerase Activity
	Biological Process	MRNA Processing RNA 3'-end Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Cytosolic MRNA Polyadenylation
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Copper levels ( 26025379) Metabolite levels ( 23823483) Number of stillbirths in continuous marriage ( 30188897) Triglyceride levels in HIV infection ( 33109212)
Novel Interacting Genes		6 novel interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE
Interacting Genes		6 interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE
Entrez ID		10914
HPRD ID		10407
Ensembl ID		ENSG00000090060
Uniprot IDs		A0A0C4DGK1 G3XAH6 P51003
PDB IDs		8R8R
Enriched GO Terms of Interacting Partners?		MRNA Cleavage And Polyadenylation Specificity Factor Complex RNA Processing MRNA Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway RNA Metabolic Process MRNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Homomeric SMAD Protein Complex Regulation Of Heart Rate By Hormone Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Spliceosomal SnRNP Complex 5'-3' RNA Exonuclease Activity Odontoblast Differentiation Mesoderm Morphogenesis SMAD Protein Complex Pericardium Development Trophoblast Cell Migration U1 SnRNP Binding Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway MRNA 3'-end Processing By Stem-loop Binding And Cleavage Nucleus Heteromeric SMAD Protein Complex U1 SnRNA Binding Determination Of Left/right Asymmetry In Lateral Mesoderm Nucleoplasm Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Embryonic Foregut Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Ubiquitin Protein Ligase Binding Dorsal/ventral Axis Specification Endoderm Formation Calcium Channel Inhibitor Activity
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