CYP46A1

Description		cytochrome P450 family 46 subfamily A member 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dendrite Cell Projection Synapse Presynapse Postsynapse
	Molecular Function	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Cholesterol 24-hydroxylase Activity Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Testosterone 16-beta-hydroxylase Activity
	Biological Process	Lipid Metabolic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Xenobiotic Metabolic Process Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process C21-steroid Hormone Metabolic Process Sterol Metabolic Process Progesterone Metabolic Process Regulation Of Biological Quality Regulation Of Long-term Synaptic Potentiation Protein Localization To Membrane Raft
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols
Drugs
Diseases
GWAS		Copper levels ( 26025379) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Pulse pressure ( 27841878) Scalp hair shape ( 26926045)
Novel Interacting Genes		4 novel interacting genes: CLK1 RIN3 TRIM55 TRIM63
Interacting Genes		4 interacting genes: CLK1 RIN3 TRIM55 TRIM63
Entrez ID		10858
HPRD ID		04970
Ensembl ID		ENSG00000036530
Uniprot IDs		Q9Y6A2
PDB IDs		2Q9F 2Q9G 3MDM 3MDR 3MDT 3MDV 4ENH 4FIA 4J14 7LRL 7LS3 7LS4 7N3L 7N3M 7N6F
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine/tyrosine Kinase Activity Transferase Activity Regulation Of Mast Cell Chemotaxis Negative Regulation Of Receptor Internalization Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size Negative Regulation Of Leukocyte Chemotaxis Ubiquitin Protein Ligase Activity Microtubule Leukocyte Migration Involved In Inflammatory Response Macrophage Migration Diapedesis Muscle Atrophy M Band Negative Regulation Of Glycolytic Process Titin Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Contractile Muscle Fiber Striated Muscle Atrophy Negative Regulation Of ATP Metabolic Process
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