MTHFD2

Description		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
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GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Catalytic Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Hydrolase Activity Phosphate Ion Binding
	Biological Process	One-carbon Metabolic Process Formate Biosynthetic Process Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process
Pathways		Metabolism of folate and pterines
Drugs		Tetrahydrofolic acid NADH
Diseases
GWAS
Novel Interacting Genes		4 novel interacting genes: DAPK1 LMNA NAGK PTEN
Interacting Genes		4 interacting genes: DAPK1 LMNA NAGK PTEN
Entrez ID		10797
HPRD ID		05351
Ensembl ID		ENSG00000065911
Uniprot IDs		P13995
PDB IDs		5TC4 6JIB 6JID 6KG2 6S4A 6S4E 6S4F 7EHJ 7EHM 7EHN 7EHV 9IS9 9ISC 9IT3 9IT6 9ITA
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Muramyl Dipeptide Kinase Activity Phosphate-containing Compound Metabolic Process Phosphorylation Cellular Response To Hydroperoxide Regulation Of Cell Communication Regulation Of Signal Transduction Postsynaptic Density Regulation Of NMDA Receptor Activity Defense Response To Tumor Cell Response To Stress Regulation Of Signaling Nuclear Lamina Negative Regulation Of Signal Transduction Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Regulation Of Protein Stability Negative Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Signaling Locomotor Rhythm Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization
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