MASP2

Description		MBL associated serine protease 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Symbiont Cell Surface
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways
Drugs		beta-Hydroxyasparagine Narsoplimab
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Appendicular lean mass ( 33097823) Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)
Novel Interacting Genes		5 novel interacting genes: C4A FCN2 MBL2 SERPING1 TNFRSF14
Interacting Genes		5 interacting genes: C4A FCN2 MBL2 SERPING1 TNFRSF14
Entrez ID		10747
HPRD ID		05484
Ensembl ID		ENSG00000009724
Uniprot IDs		A0A8V8TPN9 A0A8V8TQY3 O00187
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 5JPM
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Positive Regulation Of Opsonization Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Opsonization Defense Response To Gram-positive Bacterium Serine-type Endopeptidase Complex Regulation Of Immune System Process Positive Regulation Of Endocytosis Innate Immune Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Humoral Immune Response Antigen Binding Positive Regulation Of Immune Effector Process Complement Activation, Classical Pathway Zymogen Activation Pattern Recognition Receptor Activity Defense Response To Bacterium Protein Maturation Positive Regulation Of Immune System Process Regulation Of Endocytosis Response To Other Organism External Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response Immune Effector Process Response To Bacterium Activation Of Immune Response Response To External Biotic Stimulus Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response Collagen Trimer Calcium-dependent Protein Binding Extracellular Space Defense Response To Gram-negative Bacterium Mannan Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Immune Response Lipoteichoic Acid Immune Receptor Activity
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