NRG3

Description		neuregulin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Synapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Regulation Of Cell Growth Pattern Specification Process Nervous System Development Synapse Assembly Chemorepulsion Involved In Interneuron Migration From The Subpallium To The Cortex Mammary Gland Development Intracellular Signal Transduction ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Animal Organ Development Modulation Of Chemical Synaptic Transmission Mammary Placode Formation Negative Regulation Of Neuron Migration
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Basal metabolic rate ( 26865924) Bipolar disorder and eating disorder ( 26433762) Cardiac hypertrophy ( 21348951) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Fasting insulin (dietary factor interaction) ( 24204828) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Influenza A (H1N1) infection ( 26379185) Kidney disease (early and late stages) in type 1 diabetes ( 27647854) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Response to iloperidone treatment (QT prolongation) ( 18521091) Retinopathy in non-diabetics ( 23393555) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Venous thromboembolism ( 33592630) Western dietary pattern ( 28644415)
Novel Interacting Genes		2 novel interacting genes: ERBB4 PTPN11
Interacting Genes		2 interacting genes: ERBB4 PTPN11
Entrez ID		10718
HPRD ID		16115
Ensembl ID		ENSG00000185737
Uniprot IDs		B3KVG8 B9EGV5 D9ZHP6 P56975
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ameboidal-type Cell Migration Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Growth Factor Stimulus Heart Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuregulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Central Nervous System Morphogenesis Epidermal Growth Factor Receptor Activity Intestinal Epithelial Cell Migration Cerebellar Cortex Formation Cardiac Muscle Tissue Regeneration Developmental Growth Olfactory Bulb Interneuron Differentiation Negative Regulation Of Glucocorticoid Secretion ERBB2-ERBB4 Signaling Pathway Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB4-ERBB4 Signaling Pathway Negative Regulation Of Neutrophil Activation Microvillus Organization Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Neuron Migration ERBB4 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrioventricular Canal Development Regulation Of Neutrophil Activation Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Bergmann Glial Cell Differentiation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Growth Hormone Secretion Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation GABA Receptor Binding Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Differentiation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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