TBR1

Description		T-box brain transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding
	Biological Process	Conditioned Taste Aversion Cell Fate Specification Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Specification Of Animal Organ Identity Gene Expression Regulation Of Gene Expression Regulation Of Neuron Projection Development Amygdala Development Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Development Neuron Differentiation Hindbrain Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Intelligence (MTAG) ( 29326435) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Novel Interacting Genes		8 novel interacting genes: CASK FOXP2 HNF1B HOXA1 LRP2 MYCBP2 NFIC NFIX
Interacting Genes		8 interacting genes: CASK FOXP2 HNF1B HOXA1 LRP2 MYCBP2 NFIC NFIX
Entrez ID		10716
HPRD ID		07055
Ensembl ID		ENSG00000136535
Uniprot IDs		Q16650
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Tube Formation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Artery Development Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Genitalia Development Macromolecule Biosynthetic Process Transcription Coregulator Binding Gene Expression Nervous System Process Tube Morphogenesis Semicircular Canal Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Artery Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Putamen Development Caudate Nucleus Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Hepatoblast Differentiation Regulation Of Pronephros Size Blood Vessel Morphogenesis DNA Binding Neuromuscular Process Regulation Of RNA Metabolic Process Folate Transmembrane Transport
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