RAD51AP1

Description		RAD51 associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex
	Molecular Function	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Novel Interacting Genes		11 novel interacting genes: APP ATRX CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 NUCKS1 PALB2 RAD51 SIAH1
Interacting Genes		11 interacting genes: APP ATRX CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 NUCKS1 PALB2 RAD51 SIAH1
Entrez ID		10635
HPRD ID		04350
Ensembl ID		ENSG00000111247
Uniprot IDs		B4DUS5 F5H1Y0 Q96B01
PDB IDs
Enriched GO Terms of Interacting Partners?		Recombinational Repair Double-strand Break Repair Via Homologous Recombination Homologous Recombination DNA Strand Exchange Activity Replication Fork Processing DNA Damage Response DNA Strand Invasion DNA Recombinase Assembly Chromosome Organization Involved In Meiotic Cell Cycle Anatomical Structure Morphogenesis DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To Manganese Ion Cellular Response To Stress Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Macromolecule Metabolic Process Response To Hydroxyurea Response To Manganese Ion Lateral Element Single-stranded DNA Binding Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus DNA Metabolic Process ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Response To Catecholamine Double-stranded DNA Binding Reproductive Process Perikaryon MAP Kinase Kinase Kinase Activity Response To Stress Regulation Of Membrane Potential Response To Radiation Response To X-ray Reciprocal Meiotic Recombination Calcium-mediated Signaling Amyloid Fibril Formation Cellular Response To Radiation Chromatin Binding Nuclear Chromosome Chromosome, Telomeric Region Male Gamete Generation Spermatogenesis ATP-dependent Activity, Acting On DNA Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Gamete Generation
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