CDC42EP3

Description		CDC42 effector protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane
	Molecular Function	Protein Binding Cytoskeletal Regulatory Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly
Pathways		MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Facial attractiveness (male raters) ( 30946739) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340 28552196 23563607 20881960) Night sleep phenotypes ( 27126917) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		12 novel interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS
Interacting Genes		12 interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS
Entrez ID		10602
HPRD ID		09364
Ensembl ID		ENSG00000163171
Uniprot IDs		Q9UKI2
PDB IDs
Enriched GO Terms of Interacting Partners?		GTP Binding Nucleotide Binding GBD Domain Binding GTPase Activity Regulation Of Macrophage Activation Sperm Annulus Cytoskeleton Cytoplasm Cell Division Site Septin Ring Septin Complex Response To Type II Interferon Regulation Of SNARE Complex Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Identical Protein Binding Intracellular Signal Transduction Syntaxin-1 Binding Protein Serine Kinase Activity GTP Metabolic Process Synaptic Vesicle Protein Serine/threonine Kinase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Filopodium Assembly Regulation Of Synaptic Vesicle Recycling Endocytosis Midbody Molecular Adaptor Activity Protein Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Terminal Bouton Cellular Response To Oxidative Stress Magnesium Ion Binding Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Spindle Cleavage Furrow Import Into Cell Regulation Of Filopodium Assembly Postsynapse Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Axon Terminus
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