CENPC

Description		centromere protein C
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol Nuclear Body Midbody
	Molecular Function	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Spindle Attachment To Meiosis I Kinetochore
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Walking pace ( 33128006)
Novel Interacting Genes		8 novel interacting genes: CIP2A DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF
Interacting Genes		8 interacting genes: CIP2A DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF
Entrez ID		1060
HPRD ID		00315
Ensembl ID		ENSG00000145241
Uniprot IDs		Q03188
PDB IDs		5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF 7PII 7QOO 7R5R 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide DNA-templated Transcription Initiation RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Broken Chromosome Clustering PML Body Regulation Of RNA Metabolic Process Regulation Of Synaptic Membrane Adhesion Regulation Of Macromolecule Metabolic Process Target-directed MiRNA Degradation Elongin Complex Regulation Of Glucose Mediated Signaling Pathway Signal Transduction In Response To DNA Damage Cellular Response To Sodium Arsenite RNA Polymerase I General Transcription Initiation Factor Activity Nucleoplasm NFAT Protein Binding Response To Sodium Arsenite Cellular Response To Salt Mitogen-activated Protein Kinase P38 Binding Regulation Of Metabolic Process Stress-induced Premature Senescence Protein-DNA Complex Assembly Chromosome Protein Modification By Small Protein Conjugation Cellular Response To Stress NLRP1 Inflammasome Complex Assembly Transcription Initiation At RNA Polymerase I Promoter Protein Modification Process RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase I Preinitiation Complex Assembly
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