TXNRD2

Description		thioredoxin reductase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Dendrite Neuronal Cell Body
	Molecular Function	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Protein Homodimerization Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Response To Oxygen Radical Response To Oxidative Stress Response To Selenium Ion Cell Redox Homeostasis Response To Hyperoxia Cellular Oxidant Detoxification
Pathways		Detoxification of Reactive Oxygen Species
Drugs		Motexafin gadolinium
Diseases
GWAS		Glaucoma ( 30054594 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 29891935 33627673) Intraocular pressure ( 29785010 30054594 31959993) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)
Novel Interacting Genes		9 novel interacting genes: BCAS2 CFTR GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 SLC30A9 TADA3
Interacting Genes		9 interacting genes: BCAS2 CFTR GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 SLC30A9 TADA3
Entrez ID		10587
HPRD ID		18519
Ensembl ID		ENSG00000184470
Uniprot IDs		A0A096LPD9 E7EWK1 Q9NNW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Coactivator Activity Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Binding Circadian Behavior Rhythmic Behavior Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleotide-excision Repair Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Nucleoplasm Positive Regulation Of Biosynthetic Process Positive Regulation Of Anion Channel Activity Spindle Assembly Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Monoatomic Anion Transport Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Enamel Mineralization Circadian Rhythm Mitotic Spindle Transepithelial Water Transport Hormone-mediated Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Response To Thyroglobulin Triiodothyronine Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tooth Mineralization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Proteasome-activating Activity Spindle Organization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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