ARPC1A

Description		actin related protein 2/3 complex subunit 1A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Actin Cytoskeleton Site Of Double-strand Break Muscle Cell Projection Membrane Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Dehydroepiandrosterone sulphate levels ( 21533175) Facial emotion recognition (sad faces) ( 28608620) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Medication use (calcium channel blockers) ( 31015401) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)
Novel Interacting Genes		2 novel interacting genes: ERCC6 EXOC7
Interacting Genes		2 interacting genes: ERCC6 EXOC7
Entrez ID		10552
HPRD ID		07252
Ensembl ID		ENSG00000241685
Uniprot IDs		Q92747 V9HVZ6
PDB IDs		6YW7
Enriched GO Terms of Interacting Partners?		B-WICH Complex DNA Protection Transcription Elongation By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Response To Superoxide Pyrimidine Dimer Repair Response To Oxygen Radical Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Entry Of Bacterium Into Host Cell Growth Cone Membrane Vesicle Tethering Involved In Exocytosis Positive Regulation Of Mitotic Cytokinetic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Cell Cycle Process ATP-dependent Chromatin Remodeler Activity RNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity Protein Tyrosine Kinase Activator Activity Chromatin-protein Adaptor Activity Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Exocyst Transcription Elongation Factor Complex Positive Regulation Of Peptidyl-serine Phosphorylation Response To UV-B Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Defense Response To Virus By Host Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription By RNA Polymerase I Response To X-ray ATP-dependent Activity, Acting On DNA Regulation Of Cell Cycle Flemming Body Vesicle Tethering Negative Regulation Of DNA Repair Base-excision Repair Site Of DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Photoreceptor Cell Maintenance Regulation Of Defense Response To Virus By Host Regulation Of Transcription By RNA Polymerase I DNA Helicase Activity Negative Regulation Of Double-strand Break Repair Positive Regulation Of Cytokinesis Membrane Fission Vesicle Docking Involved In Exocytosis
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