SEMA4D

Description		semaphorin 4D
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Nucleoplasm Centrosome Plasma Membrane Membrane Ciliary Basal Body Postsynaptic Membrane GABA-ergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Neuropilin Binding Identical Protein Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Nervous System Development Axonogenesis Axon Guidance Regulation Of Cell Shape Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synapse Assembly Bone Trabecula Morphogenesis Regulation Of Biological Quality Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Inhibitory Synapse Assembly
Pathways		Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28296344) Brain morphology (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		6 novel interacting genes: CD72 CRK DSCAM LINC00839 PLXNB1 PTPRC
Interacting Genes		6 interacting genes: CD72 CRK DSCAM LINC00839 PLXNB1 PTPRC
Entrez ID		10507
HPRD ID		03520
Ensembl ID		ENSG00000187764
Uniprot IDs		E9PFD9 Q92854
PDB IDs		1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding Signaling Receptor Binding Regulation Of Locomotion Regulation Of Neuron Projection Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Development Positive Regulation Of Axonogenesis Negative Regulation Of Cell Adhesion Plasma Membrane Raft Distribution Negative Regulation Of Immune System Process Helper T Cell Diapedesis Regulation Of Catalytic Activity Protein Phosphorylated Amino Acid Binding Regulation Of Leukocyte Mediated Cytotoxicity Response To Cholecystokinin Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Locomotion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Regulation Of Cell Shape Cerebellar Neuron Development Regulation Of Axonogenesis Membrane Microdomain Regulation Of Cell Projection Organization Positive Regulation Of Cell Growth DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Immune Response Transmembrane Signaling Receptor Activity Negative Regulation Of B Cell Receptor Signaling Pathway Cell Adhesion Regulation Of Cell Motility Negative Regulation Of Immune Response Regulation Of Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Anatomical Structure Morphogenesis Diapedesis Positive Regulation Of Growth Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Endothelin Cellular Response To Endothelin Regulation Of Lymphocyte Mediated Immunity
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