TESK2

Description		testis associated actin remodelling kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Novel Interacting Genes		3 novel interacting genes: CFL1 DSTN YWHAB
Interacting Genes		3 interacting genes: CFL1 DSTN YWHAB
Entrez ID		10420
HPRD ID		05298
Ensembl ID		ENSG00000070759
Uniprot IDs		B4DFN2 Q96S53
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Fragmentation Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing Positive Regulation Of Protein Depolymerization Positive Regulation Of Protein-containing Complex Disassembly Protein Depolymerization Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Protein Localization To Cell Leading Edge Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein-containing Complex Disassembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Postsynaptic Density Organization Actin Filament Binding Regulation Of Protein Localization To Cell Leading Edge Actin Filament Organization Regulation Of Actin Filament Organization Neural Fold Formation Regulation Of Cellular Component Size Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Phosphoserine Residue Binding Regulation Of Actin Cytoskeleton Organization Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cell Size Actin Filament-based Process Positive Regulation Of Synaptic Plasticity Extracellular Exosome Focal Adhesion Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Dendritic Spine Maintenance Supramolecular Fiber Organization Vacuolar Membrane
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