SPON1

Description		spondin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding LBD Domain Binding
	Biological Process	Cell Adhesion Positive Regulation Of Protein Processing Protein Processing Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density (total hip) ( 29883787) Brain connectivity ( 23471985) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Inflammatory biomarkers ( 22228203) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) P wave terminal force ( 28794112) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Sense of smell ( 26632684) Tuberculosis ( 24057671) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		4 novel interacting genes: APP CYSRT1 MDFI MEOX2
Interacting Genes		4 interacting genes: APP CYSRT1 MDFI MEOX2
Entrez ID		10418
HPRD ID		16087
Ensembl ID		ENSG00000262655
Uniprot IDs		Q9HCB6
PDB IDs		2ZOT 2ZOU 3COO 3Q13
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Negative Regulation Of Wnt Signaling Pathway Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Somite Specification Epithelium Development Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Wnt Signaling Pathway Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion
Tagcloud ?