RAPGEF3

Description		Rap guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	Angiogenesis Adaptive Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Associative Learning Rap Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Novel Interacting Genes		15 novel interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 SP1 TGFB1 UFSP1 ZRANB1
Interacting Genes		15 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 SP1 TGFB1 UFSP1 ZRANB1
Entrez ID		10411
HPRD ID		06928
Ensembl ID		ENSG00000079337
Uniprot IDs		O95398 Q99777
PDB IDs		6H7E
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex GDP Binding Rap Protein Signal Transduction Clathrin Adaptor Activity Response To Hydroperoxide GTP Binding Hydrolase Activity Intracellular Protein Localization Establishment Of Protein Localization Regulation Of Protein Localization To Membrane Regulation Of Response To Tumor Cell DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Liver Regeneration Regulation Of Collagen Metabolic Process Response To Ketone Regulation Of Collagen Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Viral RNA Genome Packaging Retrograde Axonal Protein Transport Primary Dendrite Response To Antineoplastic Agent Small GTPase-mediated Signal Transduction Animal Organ Regeneration G Protein Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Wortmannin Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Purine Nucleoside Binding DeUFMylase Activity
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