SEMA3A

Description		semaphorin 3A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Glutamatergic Synapse
	Molecular Function	Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Neural Crest Cell Migration Neuron Migration Nervous System Development Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Neuron Projection Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Olfactory Bulb Development Branchiomotor Neuron Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Forebrain Development Positive Regulation Of JNK Cascade Sympathetic Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Sensory System Development Negative Chemotaxis Axonogenesis Involved In Innervation Sympathetic Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Basal Dendrite Arborization Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Iris characteristics ( 21835309) Major depression and alcohol dependence ( 29071344) Nose morphology ( 29921221) Obesity-related traits ( 23251661) PR interval ( 32439900) Prion diseases ( 22210626) Refractive error ( 32231278) Retinitis pigmentosa ( 33514863) Stroke ( 32693751) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196)
Novel Interacting Genes		2 novel interacting genes: NRP1 SEMA3B
Interacting Genes		2 interacting genes: NRP1 SEMA3B
Entrez ID		10371
HPRD ID		04908
Ensembl ID		ENSG00000075213
Uniprot IDs		Q14563
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Migration Semaphorin-plexin Signaling Pathway Neural Crest Cell Migration Ameboidal-type Cell Migration Axon Guidance Neuron Projection Guidance Otic Placode Development Vestibulocochlear Nerve Structural Organization Renal Artery Morphogenesis VEGF-activated Neuropilin Signaling Pathway Basal Dendrite Development Trigeminal Nerve Morphogenesis Facioacoustic Ganglion Development Endothelial Tip Cell Fate Specification Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Locomotion Chemotaxis Ventral Trunk Neural Crest Cell Migration Trigeminal Ganglion Development Basal Dendrite Arborization Sympathetic Neuron Projection Guidance Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Endothelial Cell Fate Specification Angiogenesis Involved In Coronary Vascular Morphogenesis Basal Dendrite Morphogenesis Blood Vessel Endothelial Cell Fate Specification Protein Localization To Early Endosome Vascular Endothelial Growth Factor Binding Neuropilin Signaling Pathway Chemorepulsion Of Axon Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Cranial Ganglion Development Positive Regulation Of Axon Extension Involved In Axon Guidance Sorting Endosome Trunk Neural Crest Cell Migration Neuron Projection Development Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Cell-cell Signaling Facial Nerve Structural Organization Coronary Vasculature Morphogenesis Axonogenesis Involved In Innervation Negative Regulation Of Axon Extension Involved In Axon Guidance
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