TRIM22

Description		tripartite motif containing 22
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Antiviral Innate Immune Response
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Malaria ( 31844061)
Novel Interacting Genes		13 novel interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RAF1 RERE TAF7 UBE2D1 USP7 ZZZ3
Interacting Genes		13 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RAF1 RERE TAF7 UBE2D1 USP7 ZZZ3
Entrez ID		10346
HPRD ID		05951
Ensembl ID		ENSG00000132274
Uniprot IDs		B4DQS5 Q8IYM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone Acetyltransferase Binding Positive Regulation Of Calcium Ion Import Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Hormone Transport Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction Positive Regulation Of Transforming Growth Factor Beta3 Production Hormone Secretion Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Response To Hypobaric Hypoxia MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription Chemotaxis To Arachidonate Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of NK T Cell Activation Negative Regulation Of Signal Transduction Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Calcium Ion Transport Lymphatic Endothelial Cell Migration Death-inducing Signaling Complex Assembly Negative Regulation Of MHC Class I Biosynthetic Process TFIIH-class Transcription Factor Complex Binding Spermine Transport P-TEFb Complex Binding Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling
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