TLR6

Description		toll like receptor 6
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Diacyl Lipopeptide Binding Identical Protein Binding Protein Heterodimerization Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Response To Bacterial Lipoprotein Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand RSV-host interactions
Drugs		Pam2csk4
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Novel Interacting Genes		5 novel interacting genes: BTK HRAS TLR2 TRAP1 ZYG11B
Interacting Genes		5 interacting genes: BTK HRAS TLR2 TRAP1 ZYG11B
Entrez ID		10333
HPRD ID		05656
Ensembl ID		ENSG00000174130
Uniprot IDs		B2R933 Q9Y2C9
PDB IDs		4OM7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Hypersensitivity Regulation Of Phagocytosis Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Activation Of Immune Response Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Affinity Maturation Immune Response-activating Signaling Pathway Glial Cell Development GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Triacyl Lipopeptide Binding Detection Of Diacyl Bacterial Lipopeptide Translational Attenuation Defense Response To Other Organism Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Intracellular Signal Transduction Phospholipase C Activator Activity Cellular Response To Triacyl Bacterial Lipopeptide Microglia Development Positive Regulation Of Matrix Metallopeptidase Secretion Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Cellular Response To Molecule Of Fungal Origin Regulation Of Cytokine Production Detection Of Bacterial Lipoprotein
Tagcloud ?