AKR1A1

Description		aldo-keto reductase family 1 member A1
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	Aldose Reductase (NADPH) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity Glycerol Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADH) Activity S-nitrosoglutathione Reductase (NADPH) Activity Methylglyoxal Reductase (NADPH) (acetol Producing) Activity
	Biological Process	Lipid Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate D-glucuronate Catabolic Process Negative Regulation Of Apoptotic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate
Drugs		Tolrestat Nicotinamide adenine dinucleotide phosphate Copper
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252 32888494) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		5 novel interacting genes: EXOSC4 FOXP1 HTR6 TERF1 TERF2IP
Interacting Genes		5 interacting genes: EXOSC4 FOXP1 HTR6 TERF1 TERF2IP
Entrez ID		10327
HPRD ID		00069
Ensembl ID		ENSG00000117448
Uniprot IDs		P14550 V9HWI0
PDB IDs		2ALR
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Organization Positive Regulation Of Interleukin-21 Production Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Chromosome, Telomeric Region Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Histamine Receptor Activity Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Regulation Of Chromosome Organization Ankyrin Repeat Binding Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Protection From Non-homologous End Joining At Telomere Exoribonuclease Complex Meiotic Telomere Clustering Negative Regulation Of Macromolecule Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of B Cell Receptor Signaling Pathway Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Positive Regulation Of DNA Metabolic Process Telomere Localization Telomeric D-loop Disassembly
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