SAP18

Description		Sin3A associated protein 18
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression mRNA Splicing - Major Pathway Potential therapeutics for SARS
Drugs
Diseases
GWAS
Novel Interacting Genes		16 novel interacting genes: DEF6 ERBB3 HDAC1 IFT88 IKZF1 INCA1 KRT5 NOL12 NTAQ1 POLE2 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2
Interacting Genes		16 interacting genes: DEF6 ERBB3 HDAC1 IFT88 IKZF1 INCA1 KRT5 NOL12 NTAQ1 POLE2 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2
Entrez ID		10284
HPRD ID		04256
Ensembl ID		ENSG00000150459
Uniprot IDs		O00422
PDB IDs		2HDE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Sin3-type Complex Transcription Corepressor Activity Nucleus Histone Deacetylase Complex Negative Regulation Of Stem Cell Population Maintenance Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Intermediate Filament Polymerization Ciliary Tip Ciliary Base Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Response To Methylglyoxal Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Programmed Cell Death ERBB3:ERBB2 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Krueppel-associated Box Domain Binding Intermediate Filament Polymerization Or Depolymerization Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Stem Cell Population Maintenance
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