FAM13A

Description		family with sequence similarity 13 member A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	GTPase Activator Activity
	Biological Process	Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOA GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 20173748 22080838 25101718 25241909 30804561 28166215) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Fasting insulin ( 34059833) Glaucoma (primary open-angle) ( 33627673) Hair greying ( 26926045) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Idiopathic pulmonary fibrosis ( 31710517) Insular cortex volume ( 31530798) Interstitial lung disease ( 23583980) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Longevity ( 26912274) Lung function ( 31902109) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean platelet volume ( 32888494) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878 30578418) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28430825 25673412)
Novel Interacting Genes		2 novel interacting genes: RAC1 SHANK3
Interacting Genes		2 interacting genes: RAC1 SHANK3
Entrez ID		10144
HPRD ID		10944
Ensembl ID		ENSG00000138640
Uniprot IDs		O94988
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Central Nervous System Neuron Differentiation Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of Synaptic Plasticity Regulation Of ERK5 Cascade Regulation Of Actin Filament Organization Angiotensin-activated Signaling Pathway Involved In Heart Process Neuron Projection Morphogenesis Postsynaptic Membrane Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Cellular Component Size Guanylate Kinase-associated Protein Clustering Cell Projection Morphogenesis Regulation Of Synapse Organization Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Protein Localization To Membrane Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of Ovarian Follicle Development Regulation Of Supramolecular Fiber Organization Erythrocyte Enucleation Neuron Differentiation Regulation Of Actin Filament-based Process Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Kinocilium Localization Within Membrane Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Neuron Projection Development Cell Junction Organization Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Regulation Of Cytoskeleton Organization Tangential Migration From The Subventricular Zone To The Olfactory Bulb Vocal Learning Neuron Spine Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity
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