ARPC5

Description		actin related protein 2/3 complex subunit 5
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Cortical Cytoskeleton Secretory Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS
Novel Interacting Genes		6 novel interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1
Interacting Genes		6 interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1
Entrez ID		10092
HPRD ID		11969
Ensembl ID		ENSG00000162704
Uniprot IDs		O15511
PDB IDs		6UHC 6YW7
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Actin Filament Binding Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Actin Cytoskeleton Meiotic Cytokinesis Actin Binding Site Of Double-strand Break Asymmetric Cell Division Supramolecular Fiber Organization Cytoskeleton Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Extracellular Exosome Regulation Of Lamellipodium Organization Spindle Localization Cellular Response To Type II Interferon Focal Adhesion Nuclear Glucocorticoid Receptor Activity Cell Division Tubulobulbar Complex Chromosome Localization Cytoskeleton-dependent Cytokinesis Response To Type II Interferon Response To Cytokine Response To Peptide Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Cell Cycle Cytosol Establishment Or Maintenance Of Cell Polarity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Actin Cap Nuclear Receptor-mediated Corticosteroid Signaling Pathway Response To Lipid Steroid Hormone Binding Calcium-dependent Protein Serine/threonine Kinase Activity Response To Cortisol Macropinocytosis Actin Polymerization-dependent Cell Motility Nucleus Regulation Of Cell Projection Assembly Mammary Gland Duct Morphogenesis Microglia Differentiation Cilium Assembly Regulation Of Glucocorticoid Biosynthetic Process Cellular Response To Growth Factor Stimulus
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