PQBP1

Description		polyglutamine binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Cytoplasmic Stress Granule Microtubule Cytoskeleton Nuclear Body Nuclear Speck Ciliary Basal Body Neuronal Ribonucleoprotein Granule Plasma Membrane Bounded Cell Projection
	Molecular Function	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Novel Interacting Genes		27 novel interacting genes: APBB1 APP AQR ATXN1 CEBPA CLTB CPSF7 EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RBM22 RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Interacting Genes		27 interacting genes: APBB1 APP AQR ATXN1 CEBPA CLTB CPSF7 EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RBM22 RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		10084
HPRD ID		02354
Ensembl ID		ENSG00000102103
Uniprot IDs		A0A0S2Z4V5 O60828
PDB IDs		4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of RNA Splicing
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