CDH6

Description		cadherin 6
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Cell Junction Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Notch Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion Synaptic Membrane Adhesion
Pathways		Adherens junctions interactions
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Cocaine dependence ( 31212010) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Emphysema-related traits ( 20709820) Gamma glutamyl transferase levels ( 33339817 29403010) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Late-onset myasthenia gravis ( 26562150) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Resting heart rate ( 27798624) Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Sleep (1/3-day periodicity) ( 33075057) Smoking status (ever vs never smokers) ( 30643258) Sweet taste preference ( 32572145) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Novel Interacting Genes		6 novel interacting genes: CDH10 CDH18 CDH19 CDH7 CDH9 DNAH5
Interacting Genes		6 interacting genes: CDH10 CDH18 CDH19 CDH7 CDH9 DNAH5
Entrez ID		1004
HPRD ID		04305
Ensembl ID		ENSG00000113361
Uniprot IDs		P55285
PDB IDs		5VEB
Enriched GO Terms of Interacting Partners?		Catenin Complex Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Beta-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Assembly Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell Motility Cell Junction Organization Cell-cell Adhesion Calcium Ion Binding Cell Adhesion Cell Migration Cellular Component Assembly Anatomical Structure Morphogenesis Synaptic Membrane Adhesion Developmental Process 9+0 Motile Cilium Metal Ion Binding Outer Dynein Arm Axonemal Dynein Complex Lateral Ventricle Development Minus-end-directed Microtubule Motor Activity Plasma Membrane Outer Dynein Arm Assembly Glial Cell Projection Dynein Light Intermediate Chain Binding Presynaptic Active Zone Membrane Postsynaptic Specialization Membrane 9+2 Motile Cilium Dynein Intermediate Chain Binding Dynein Complex Axonemal Dynein Complex Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Microtubule Motor Activity
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